PRECLINICAL RESEARCH CLINICAL APPLICATION ? Independently of diet, the gut microbiota is able to influence host inflammatory responses. Esteve E, Ricart W, Fernández-Real J. Arumugam M, Raes J, Pelletier E, Le Paslier D, Yamada T, Mende D, et al. Macia L, Thorburn A, Binge L, Marino E, Rogers K, Maslowski K, et al. A factor recently studied as a cause of obesity is gut microbiota, defined as the communities of living microorganisms that colonise the intestines. Gut microbiota and obesity (microbiota, obesity, prebiotics) Renata Barczyńska Institute of Chemistry, Environmental Protection and Biotechnology, Jan Dlugosz University in Czestochowa, Poland (e-mail: r.barczynska@gmail.com) The etiology of obesity reflects complex interactions among genetic and environmental factors, with current high energy diets and sedentary lifestyle considered to be fo obesity, insulin resistance and type 2 diabetes: did gut microbiote co-evolve It is known that the gut microbiota contributes significantly to the two main functions of the gastrointestinal tract: nutrition and defence. Several recent science studies have claimed that the gut microbiome -- the diverse array of bacteria that live in the stomach and intestines -- may be to blame for obesity. Animal and human studies have implicated distortion of the normal microbial balance in obesity and metabolic syndrome. 9. Studies have shown that individuals with obesity have created an “obesity signature” inside their gut microbiome that has shaped how their metabolism functions. The composition of the gut microbiota has received attention as an etiological factor in the development of obesity. 1. The Journal of Clinical : The contributory role of gut microbiota in cardiovascular disease. Recent studies have suggested that gut bacteria play a fundamental role in diseases such as obesity, diabetes and cardiovascular disease. Hypercaloric diets are tightly related to the obesity etiology and also cause alterations in gut microbiota functionality. Here, we aimed to explore the gut microbiome and memory domains according to obesity status. 180. It is sensitive to dietary changes and able to alter composition within hours in both animals and humans (2-5). 4. References. These diurnal patterns are aberrant in obesity. The gut microbiota affects numerous biological functions throughout the body and its characterisation has become a major research area in biomedicine. Presentation Summary : Obesity and gut microbiota. Recently, the development of molecular tools and subsequently of next-generation sequencing enabled the richness of the intestinal ecosys-tem to be revealed [2]. and SCFA in Lean and Overweight Healthy Subjects. Gut microbiota has evolved with humans as a mutualistic partner; however, changes in the composition of the gut microbiota (dysbiosis) have been found to be related with several clinical conditions such as obesity, diabetes, fatty liver disease, atherosclerosis, allergic diseases, gastrointestinal diseases, autoimmune diseases, and cancer. After absorbed, … Increased food intake and lack of exercise are two main contributing factors. Evidence suggests that the GI microbiota in the obese is different from the normal weight subject. 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